San Diego is 74% more expensive than Port St. Lucie.
When comparing San Diego, CA and Port St. Lucie, FL, the overall cost of living indices are 197 and 113 respectively (national median = 100). Rent is $442/month cheaper in Port St. Lucie, saving renters about $5,304/year.
Median household income is $26,184/year higher in San Diego. Home values also differ significantly — the median in San Diego is $848,500 compared to $327,700 in Port St. Lucie.
Florida has no state income tax, giving Port St. Lucie residents a significant tax advantage over California's 13.3% rate.
San Diego vs Port St. Lucie — common questions
Other cost of living comparisons for San Diego and Port St. Lucie