San Diego is 44% more expensive than Santa Maria.
When comparing San Diego, CA and Santa Maria, CA, the overall cost of living indices are 197 and 137 respectively (national median = 100). Rent is $381/month cheaper in Santa Maria, saving renters about $4,572/year.
Median household income is $19,704/year higher in San Diego. Home values also differ significantly — the median in San Diego is $848,500 compared to $478,200 in Santa Maria.
Both cities share the same state tax structure since they are in California.
San Diego vs Santa Maria — common questions
Other cost of living comparisons for San Diego and Santa Maria