Boston is 167% more expensive than St. Louis.
When comparing Boston, MA and St. Louis, MO, the overall cost of living indices are 176 and 66 respectively (national median = 100). Rent is $1,115/month cheaper in St. Louis, saving renters about $13,380/year.
Median household income is $39,476/year higher in Boston. Home values also differ significantly — the median in Boston is $710,400 compared to $185,100 in St. Louis.
Missouri has a lower income tax rate, making St. Louis slightly more tax-friendly.
Boston vs St. Louis — common questions
Other cost of living comparisons for Boston and St. Louis