Boston is 66% more expensive than St. Petersburg.
When comparing Boston, MA and St. Petersburg, FL, the overall cost of living indices are 176 and 106 respectively (national median = 100). Rent is $551/month cheaper in St. Petersburg, saving renters about $6,612/year.
Median household income is $21,637/year higher in Boston. Home values also differ significantly — the median in Boston is $710,400 compared to $331,500 in St. Petersburg.
Florida has no state income tax, giving St. Petersburg residents a significant tax advantage over Massachusetts's 9.0% rate.
Boston vs St. Petersburg — common questions
Other cost of living comparisons for Boston and St. Petersburg