Denver is 39% more expensive than St. Petersburg.
When comparing Denver, CO and St. Petersburg, FL, the overall cost of living indices are 147 and 106 respectively (national median = 100). Rent is $228/month cheaper in St. Petersburg, saving renters about $2,736/year.
Median household income is $18,563/year higher in Denver. Home values also differ significantly — the median in Denver is $586,700 compared to $331,500 in St. Petersburg.
Florida has no state income tax, giving St. Petersburg residents a significant tax advantage over Colorado's 4.4% rate.
Denver vs St. Petersburg — common questions
Other cost of living comparisons for Denver and St. Petersburg