Jacksonville is 39% more expensive than St. Louis.
When comparing Jacksonville, FL and St. Louis, MO, the overall cost of living indices are 92 and 66 respectively (national median = 100). Rent is $397/month cheaper in St. Louis, saving renters about $4,764/year.
Median household income is $11,702/year higher in Jacksonville. Home values also differ significantly — the median in Jacksonville is $266,100 compared to $185,100 in St. Louis.
Florida has no state income tax, giving Jacksonville residents a significant tax advantage over Missouri's 4.95% rate.
Jacksonville vs St. Louis — common questions
Other cost of living comparisons for Jacksonville and St. Louis