San Diego is 86% more expensive than St. Petersburg.
When comparing San Diego, CA and St. Petersburg, FL, the overall cost of living indices are 197 and 106 respectively (national median = 100). Rent is $681/month cheaper in St. Petersburg, saving renters about $8,172/year.
Median household income is $31,203/year higher in San Diego. Home values also differ significantly — the median in San Diego is $848,500 compared to $331,500 in St. Petersburg.
Florida has no state income tax, giving St. Petersburg residents a significant tax advantage over California's 13.3% rate.
San Diego vs St. Petersburg — common questions
Other cost of living comparisons for San Diego and St. Petersburg