San Francisco is 4% more expensive than Irvine.
When comparing San Francisco, CA and Irvine, CA, the overall cost of living indices are 267 and 256 respectively (national median = 100). Rent is $474/month cheaper in San Francisco, saving renters about $5,688/year.
Median household income is $11,799/year higher in San Francisco. Home values also differ significantly — the median in San Francisco is $1,380,500 compared to $1,115,400 in Irvine.
Both cities share the same state tax structure since they are in California.
San Francisco vs Irvine — common questions
Other cost of living comparisons for San Francisco and Irvine