San Francisco is 152% more expensive than Manchester.
When comparing San Francisco, CA and Manchester, NH, the overall cost of living indices are 267 and 106 respectively (national median = 100). Rent is $954/month cheaper in Manchester, saving renters about $11,448/year.
Median household income is $64,031/year higher in San Francisco. Home values also differ significantly — the median in San Francisco is $1,380,500 compared to $336,300 in Manchester.
New Hampshire has no state income tax, giving Manchester residents a significant tax advantage over California's 13.3% rate.
San Francisco vs Manchester — common questions
Other cost of living comparisons for San Francisco and Manchester