San Francisco is 150% more expensive than Mesa.
When comparing San Francisco, CA and Mesa, AZ, the overall cost of living indices are 267 and 107 respectively (national median = 100). Rent is $941/month cheaper in Mesa, saving renters about $11,292/year.
Median household income is $62,667/year higher in San Francisco. Home values also differ significantly — the median in San Francisco is $1,380,500 compared to $364,300 in Mesa.
Arizona has a lower income tax rate, making Mesa slightly more tax-friendly.
San Francisco vs Mesa — common questions
Other cost of living comparisons for San Francisco and Mesa