San Francisco is 136% more expensive than Port St. Lucie.
When comparing San Francisco, CA and Port St. Lucie, FL, the overall cost of living indices are 267 and 113 respectively (national median = 100). Rent is $638/month cheaper in Port St. Lucie, saving renters about $7,656/year.
Median household income is $63,309/year higher in San Francisco. Home values also differ significantly — the median in San Francisco is $1,380,500 compared to $327,700 in Port St. Lucie.
Florida has no state income tax, giving Port St. Lucie residents a significant tax advantage over California's 13.3% rate.
San Francisco vs Port St. Lucie — common questions
Other cost of living comparisons for San Francisco and Port St. Lucie