San Francisco is 64% more expensive than Santa Ana.
When comparing San Francisco, CA and Santa Ana, CA, the overall cost of living indices are 267 and 163 respectively (national median = 100). Rent is $444/month cheaper in Santa Ana, saving renters about $5,328/year.
Median household income is $53,092/year higher in San Francisco. Home values also differ significantly — the median in San Francisco is $1,380,500 compared to $657,800 in Santa Ana.
Both cities share the same state tax structure since they are in California.
San Francisco vs Santa Ana — common questions
Other cost of living comparisons for San Francisco and Santa Ana