San Francisco is 13% cheaper than Santa Clara.
When comparing San Francisco, CA and Santa Clara, CA, the overall cost of living indices are 267 and 307 respectively (national median = 100). Rent is $566/month cheaper in San Francisco, saving renters about $6,792/year.
Median household income is $32,224/year higher in Santa Clara. Home values also differ significantly — the median in San Francisco is $1,380,500 compared to $1,527,900 in Santa Clara.
Both cities share the same state tax structure since they are in California.
San Francisco vs Santa Clara — common questions
Other cost of living comparisons for San Francisco and Santa Clara