San Francisco is 95% more expensive than Santa Maria.
When comparing San Francisco, CA and Santa Maria, CA, the overall cost of living indices are 267 and 137 respectively (national median = 100). Rent is $577/month cheaper in Santa Maria, saving renters about $6,924/year.
Median household income is $56,829/year higher in San Francisco. Home values also differ significantly — the median in San Francisco is $1,380,500 compared to $478,200 in Santa Maria.
Both cities share the same state tax structure since they are in California.
San Francisco vs Santa Maria — common questions
Other cost of living comparisons for San Francisco and Santa Maria