San Francisco is 136% more expensive than Tampa.
When comparing San Francisco, CA and Tampa, FL, the overall cost of living indices are 267 and 113 respectively (national median = 100). Rent is $852/month cheaper in Tampa, saving renters about $10,224/year.
Median household income is $70,144/year higher in San Francisco. Home values also differ significantly — the median in San Francisco is $1,380,500 compared to $375,300 in Tampa.
Florida has no state income tax, giving Tampa residents a significant tax advantage over California's 13.3% rate.
San Francisco vs Tampa — common questions
Other cost of living comparisons for San Francisco and Tampa