St. Louis is 45% cheaper than Lowell.
When comparing St. Louis, MO and Lowell, MA, the overall cost of living indices are 66 and 119 respectively (national median = 100). Rent is $625/month cheaper in St. Louis, saving renters about $7,500/year.
Median household income is $20,926/year higher in Lowell. Home values also differ significantly — the median in St. Louis is $185,100 compared to $395,100 in Lowell.
Missouri has a lower income tax rate, making St. Louis slightly more tax-friendly.
St. Louis vs Lowell — common questions
Other cost of living comparisons for St. Louis and Lowell