St. Louis is 8% more expensive than Rochester.
When comparing St. Louis, MO and Rochester, NY, the overall cost of living indices are 66 and 61 respectively (national median = 100). Rent is $61/month cheaper in St. Louis, saving renters about $732/year.
Median household income is $8,651/year higher in St. Louis. Home values also differ significantly — the median in St. Louis is $185,100 compared to $120,600 in Rochester.
Missouri has a lower income tax rate, making St. Louis slightly more tax-friendly.
St. Louis vs Rochester — common questions
Other cost of living comparisons for St. Louis and Rochester