St. Louis is 15% cheaper than Sioux Falls.
When comparing St. Louis, MO and Sioux Falls, SD, the overall cost of living indices are 66 and 78 respectively (national median = 100). Rent is comparable in both cities, with less than $50/month separating them.
Median household income is $19,435/year higher in Sioux Falls. Home values also differ significantly — the median in St. Louis is $185,100 compared to $271,400 in Sioux Falls.
South Dakota has no state income tax, giving Sioux Falls residents a significant tax advantage over Missouri's 4.95% rate.
St. Louis vs Sioux Falls — common questions
Other cost of living comparisons for St. Louis and Sioux Falls