Louisville is 12% more expensive than St. Louis.
When comparing Louisville, KY and St. Louis, MO, the overall cost of living indices are 74 and 66 respectively (national median = 100). Rent is $91/month cheaper in St. Louis, saving renters about $1,092/year.
Median household income is $9,452/year higher in Louisville. Home values also differ significantly — the median in Louisville is $221,500 compared to $185,100 in St. Louis.
Kentucky has a lower income tax rate, making Louisville slightly more tax-friendly.
Louisville vs St. Louis — common questions
Other cost of living comparisons for Louisville and St. Louis