Louisville is 30% cheaper than St. Petersburg.
When comparing Louisville, KY and St. Petersburg, FL, the overall cost of living indices are 74 and 106 respectively (national median = 100). Rent is $473/month cheaper in Louisville, saving renters about $5,676/year.
Median household income is $8,387/year higher in St. Petersburg. Home values also differ significantly — the median in Louisville is $221,500 compared to $331,500 in St. Petersburg.
Florida has no state income tax, giving St. Petersburg residents a significant tax advantage over Kentucky's 4.0% rate.
Louisville vs St. Petersburg — common questions
Other cost of living comparisons for Louisville and St. Petersburg