San Francisco is 152% more expensive than St. Petersburg.
When comparing San Francisco, CA and St. Petersburg, FL, the overall cost of living indices are 267 and 106 respectively (national median = 100). Rent is $877/month cheaper in St. Petersburg, saving renters about $10,524/year.
Median household income is $68,328/year higher in San Francisco. Home values also differ significantly — the median in San Francisco is $1,380,500 compared to $331,500 in St. Petersburg.
Florida has no state income tax, giving St. Petersburg residents a significant tax advantage over California's 13.3% rate.
San Francisco vs St. Petersburg — common questions
Other cost of living comparisons for San Francisco and St. Petersburg